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INTERNATIONAL CONGRESS OF

CancerGenetics

• Epigenetics in Breast Cancer: From Molecular Mechanisms to Novel Therapeutic Approaches

• Kiana Mohammadi,^1,* Bita Avarki,² Narges Soroush,³ Faranak Farjoudi Niay Kasma,⁴ Zahra Moghadam,⁵
  1. Ph.D. Candidate of Molecular Genetics, Department of Biology, Faculty of Science, Islamic Azad University, Damghan Branch, Tehran, Iran
  2. BSc Student in Cellular and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University, Shahre Qods Branch, Tehran, Iran
  3. B.Sc. Student in Cell and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University, Shahre Qods Branch, Tehran, Iran
  4. B.Sc. Student in Cell and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University, Shahre Qods Branch, Tehran, Iran
  5. B.Sc. Student in Cell and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University, Shahre Qods Branch, Tehran, Iran
  
  
  
• Introduction: Breast cancer, the most common malignancy in women, involves reversible epigenetic changes DNA methylation, histone modifications, and non-coding RNAs that regulate tumor initiation, progression, and therapy resistance
• Methods: A narrative review was conducted by synthesizing current studies on epigenetic mechanisms in breast cancer
• Results: DNA hypermethylation silences tumor suppressor genes, while global hypomethylation activates oncogenes. Dysregulated histone-modifying enzymes and non-coding RNAs promote malignancy and drug resistance. DNMT and HDAC inhibitors show therapeutic potential but are limited by toxicity and resistance. Emerging strategies, including combination therapies, nanomedicine delivery, and personalized epigenetic profiling, offer improved treatment opportunities
• Conclusion: Targeting epigenetic mechanisms may enhance therapy efficacy and improve patient outcomes
• Keywords: Breast cancer، Epigenetics،DNA methylation، Histone modifications،Epidrugs، Nanomedicine