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INTERNATIONAL CONGRESS OF

CancerGenetics

• Genomic comparison of feline and human mammary tumors: new insights for cancer modeling.

• Amjad Salimi,^1,* Diako Sadeghi,² Arghavan Mohmmadi Ali abadi,³ Mahsa farhodi Moghadam,⁴
  1. University of Kurdistan iran
  2. Islamic Azad University of Sanandaj
  3. Islamic Azad University, Sanandaj Branch
  4. Islamic Azad University, Sanandaj Branch
  
  
  
• Introduction: breast cancer , being the most prevalent from of cancer in women, has long been a subject of interest for researchers. with the considerable progress made in diagnosis and treatment, there is a growing demand for effective animal model to gain a deeper understanding of the molecular mechanisms involved and to develop more effective therapeutic approaches. researchers have found striking similarities between subtypes of feline mammary tumors and the human counterpatrs from genes to pathways involved in cancer initiation and progression. spontaneous prienvasive intraepithelial lesions of the feline mammary gland and malignant lesions appear to share a board set of molecular features with their human counterpatrs. this review summarizes all published genetic aspects of feline mammary tumors, supporting the use of cats as a valuable alternative in cell animal model , including mammary cell lines and spontaneous tumors.
• Methods: research methodology this study used a systematic literature review (SLR) methodology, as recommended by carrion etal., (2020) . the SLR methodology uses a thorough and distinict approach to synthesizing research , with the primary goal of assessing and miniminzing bias in fidings (bearman and dawson2013) to obtain a comprehnsive analysis of the relevant literature , articles from four popular academic databases.
• Results: while a growing number of studies emphasize the importance of feline mammray cancers (FMS) model, there is still no consensus among them. this is a shortcoming , as there is little research on the experssion of cancer- related genes that could provide a better understanding of FMCs at the molecular level. feline mammary tumor cell lines are invaluable as laboratory models for cancer research and, once fully characterization have significant clinical relevance .proper characterized is essential to provide important insights into the complexity of cancer etiology and the biological mechanisms involved , and allows for the informed selection of the appropriate cell line for the specific research being conducted.
• Conclusion: the use of appropriate model is crucial for both basic and clinical research on breast cancer. these models provide conceptual tools that aid in understanding the biology of the disease and allow for more accurate patient stratification for targeted therapies. this knowledge is not only important for the development of new anticancer treatments, but also for the more efficient use of currently available drugs. the cat has the potential to be a valuable alternative cancer model, and is likely to be a superior model for cancer genetics compared to other commonly used models. however, further research is needed to fully utilize the potential of cat cancer genetics
• Keywords: feline mammary cancers- cellular and animal model- cancerous tumor- breast cancer