INTERNATIONAL CONGRESS OF
CancerGenetics
Expression of lncRNAs DLEU1 and DLEU2 in Ovarian Cancer and Their Association with Clinicopathological Features
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Leila Rezvan,1 Nader Farsad Akhtar,2,* Reza Safaralizadeh,3 Ali Rajabi,4
1. Department of Plant, Cell and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2. Department of Plant, Cell and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
3. Department of Animal Biology, Faculty of Natural Sciences, The University of Tabriz, Tabriz, Iran
4. Department of Animal Biology, Faculty of Natural Sciences, The University of Tabriz, Tabriz, Iran
- Introduction: Ovarian cancer is among the most lethal gynecologic malignancies, often diagnosed at advanced stages due to the lack of effective early detection markers. Long non-coding RNAs (lncRNAs) have emerged as critical regulators in cancer biology. This study evaluates the expression of two lncRNAs, DLEU1 and DLEU2, in ovarian cancer tissues and their potential as diagnostic biomarkers.
- Methods: A total of 55 paired ovarian tumor and adjacent non-tumor tissue samples were analyzed using qRT-PCR to assess DLEU1 and DLEU2 expression. ROC curve analysis was conducted to evaluate diagnostic performance, and associations with clinicopathological features were examined
- Results: DLEU1 was significantly overexpressed in tumor tissues compared to controls (p < 0.0001), while DLEU2 showed no significant differential expression (p = 0.3260). ROC analysis revealed moderate diagnostic value for DLEU1 (AUC = 0.7071), with 70.0% sensitivity and 67.27% specificity. DLEU2 showed lower diagnostic performance (AUC = 0.6179) but remained statistically significant. No correlation was found between gene expression and clinical features.
- Conclusion: DLEU1 may serve as a moderate diagnostic biomarker for ovarian cancer. While DLEU2 did not demonstrate strong independent diagnostic utility, it may hold value in multi-biomarker panels. Further studies are warranted to explore the functional role of these lncRNAs in tumor progression.
- Keywords: Ovarian cancer, DLEU1, DLEU2, qRT-PCR, Diagnostic biomarker
