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INTERNATIONAL CONGRESS OF

CancerGenetics

• Diagnostic and Prognostic Potential of Serum Long Noncoding RNAs MVIH, HNF1A-AS1, and NEAT1 in Colorectal Cancer

• Touraj Asvadi Kermani,¹ Mohammad-Reza Firoozi,² Shahriar Hashemzadeh,³ Venus Zafari,⁴ Rojin Farzaneh,⁵ Leila Vahedi,^6,*
  1. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  2. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  3. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  4. Department of Basic Oncology, Health Institute of Ege University, Izmir, Turkey.
  5. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  6. Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  
  
  
• Introduction: Long noncoding RNAs (lncRNAs) are a major class of regulatory RNA molecules that play essential roles in gene expression, chromatin remodeling, and cancer progression. This study aimed to evaluate the serum expression levels of MVIH, HNF1A-AS1, and NEAT1 in colorectal cancer (CRC) patients before and three months after surgery, compared with healthy controls, to explore their potential as epigenetic biomarkers.
• Methods: Serum samples were collected from 75 CRC patients (pre- and post-surgery) and 75 healthy individuals. Relative expression levels of MVIH, HNF1A-AS1, and NEAT1 were quantified using quantitative real-time PCR (qRT-PCR). Statistical and receiver operating characteristic (ROC) analyses were conducted to determine their diagnostic and prognostic significance.
• Results: The serum expression of MVIH, HNF1A-AS1, and NEAT1 was significantly upregulated in CRC patients compared with healthy controls. ROC curve analysis indicated that all three lncRNAs could effectively distinguish CRC patients from controls with high diagnostic accuracy. Notably, three months after surgery, the serum levels of MVIH, HNF1A-AS1, and NEAT1 were significantly downregulated. No significant correlations were observed between serum lncRNA expression and clinicopathological parameters.
• Conclusion: Aberrant expression of circulating MVIH, HNF1A-AS1, and NEAT1 reflects underlying epigenetic dysregulation in colorectal cancer and highlights their potential as noninvasive biomarkers for CRC diagnosis and prognosis.
• Keywords: Epigenetics, Colorectal cancer, Long noncoding RNAs, Biomarkers, Gene regulation