INTERNATIONAL CONGRESS OF
CancerGenetics
Prognostic Circulatory Non-coding RNAs and Their Potential Targets in Human Breast Cancer
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Babak Pourgholamali,1 Nazanin Mehrzad,2 Habib Ghaznavi,3 Roghayeh Sheervalilou,4,*
1. Guilan University of Medical Sciences
2. Science and Research Branch Islamic Azad university
3. Zahedan University of Medical Sciences
4. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
- Introduction: Breast cancer (BC), a disease with both genetic and environmental roots, remains a significant cause of mortality in women. Crucially, early detection can prevent the progression of the disease through invasion and metastasis.
- Methods: This study addresses the urgent need for non-invasive biological markers in body fluids by exploring the potential of circulating non-coding RNAs, particularly microRNAs (miRNAs), as prognostic and detective biomarkers.
- Results: Through a robust bioinformatics pipeline, we analyzed miRNA expression profiles from multiple datasets using the limma package in R to identify miRNAs differentially expressed in BC patients compared to healthy individuals. Further investigation of the predicted target genes for these differentially expressed miRNAs, facilitated by the Multimir package in R and functional enrichment analysis via Enrich R, revealed their enrichment in critical cellular functions, including the mitochondrial outer membrane, intrinsic apoptotic signaling regulation, and transcription co-receptor activity, as well as their involvement in the dopaminergic synapse pathway.
- Conclusion: Most notably, our survival analysis identified miR-29c as promising prognostic biomarkers, offering valuable insights for future BC diagnostics and prognostics.
- Keywords: Prognostic Circulatory Non-coding RNAs, and Potential Targets, Human Breast Cancer
