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INTERNATIONAL CONGRESS OF

CancerGenetics

• Evaluation of miR-98-5P and GAB2 gene expression in endometriosis

• Javad Fazeli,¹ Mehran Dehghanian,² Ghafour Yarahmadi,³ Maryam Shirmohamadi,⁴ Emad Babakhanzadeh,⁵ Mohamadhasan Sheikhha,^6,*
  1. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  
  
  
• Introduction: Background: GAB2 (Grb2-associated binding protein 2) is a member of the DOS/GAB family of scaffold adaptors that transduce and amplify tyrosine kinase receptor signaling. Recent studies suggest that increased expression of GAB2 promotes tumor progression by enhancing cell proliferation and migration. Studies on the expression of microRNAs have the potential to be useful in the detection, prevention and treatment of various diseases. The anti-cancer effect of Mir-98-5p has been demonstrated in various types of cancer. The aim of this study was to evaluate the gene expression of miR-98-5p and GAB2 in individuals with endometriosis compared to the control group.
• Methods: In this study, eutopic and ectopic samples were taken from 15 women with endometriosis. The control group consisted of samples from 15 women with normal endometrium and no signs of endometriosis. Quantitative polymerase chain reaction (RT-qPCR) was used to measure the expression of the miR-98-5p and GAB2 genes.
• Results: Results: We found a remarkable increase in GAB2 expression and a significant decrease in miR-98-5p expression in subjects with endometriosis compared to the normal group.
• Conclusion: Conclusion: Based on the results obtained, it appears that miR-98-5p could serve as a diagnostic and curative biomarker for individuals with endometriosis.
• Keywords: Endometriosis Gene expression GAB2 miR-98-5p