INTERNATIONAL CONGRESS OF
CancerGenetics
The Role of the Microbiome in Cancer Prevention and Therapy
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Kiana Mohammadi,1,* Amir Hossein Rahimi,2
1. Ph.D. Candidate of Molecular Genetics, Department of Biology, Faculty of Science, Islamic Azad University, Damghan Branch, Tehran, Iran
2. BSc Student in Cellular and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University, Shahre Qods Branch, Tehran, Iran
- Introduction: The gut microbiome, consisting of bacteria, fungi, and viruses, is crucial for human health. Dysbiosis is linked to chronic diseases and cancers, notably colorectal and oral cancers
- Methods: We reviewed 16S rRNA sequencing studies and integrated genomic, metabolomic, and transcriptomic data, along with clinical and preclinical findings on microbiome-based interventions
- Results: Microbial changes are associated with colorectal and oral cancers. The gut microbiome can serve as a non-invasive biomarker for diagnosis and predicting treatment response. Interventions such as probiotics and antibiotics may improve therapeutic outcomes and reduce side effects
- Conclusion: The gut microbiome is a promising biomarker and therapeutic target for personalized cancer therapy, offering new opportunities for prevention and treatment
- Keywords: Microbiome, Cancer, Personalized Therapy, Dysbiosis, Biomarker, Probiotics, Antibiotics
