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  • Integrative Bioinformatic Profiling Reveals microRNA-Driven SOD2 Suppression in Brain Neoplasms

  • Negar Zamani Alavijeh,1,* Maryam Ghadiri,2
    2. Isfahan


  • Introduction: Brain neoplasms represent a heterogeneous group of tumors with significant molecular complexity. Identifying dysregulated genes and their regulatory microRNAs (miRNAs) can provide valuable insights into tumorigenesis and potential therapeutic targets. Superoxide dismutase 2 (SOD2), a key mitochondrial antioxidant enzyme, has been implicated in various cancers, but its regulatory network in brain neoplasms remains insufficiently understood.
  • Methods: Gene expression data related to Brain Neoplasms were retrieved from the NCBI GEO database. The dataset GSE15824 was selected and categorized into cancer and normal groups. Differential expression analysis was performed using GEO2R, applying statistical filters to identify significantly altered genes. SOD2 emerged as a markedly downregulated gene in tumor samples. To explore its upstream regulatory elements, the HMDD database was used to identify miRNAs associated with SOD2. These miRNAs were further evaluated for their potential involvement in brain neoplasm pathology.
  • Results: Analysis of GSE15824 revealed a significant reduction in SOD2 expression in brain neoplasm samples compared to normal tissues. Statistical outputs and expression plots from GEO2R consistently supported this downregulation. HMDD screening identified multiple miRNAs predicted or validated to target SOD2. The regulatory network suggests that these miRNAs may contribute to tumor development by suppressing SOD2 expression, thereby reducing antioxidant defense and promoting cellular stress pathways associated with tumor progression.
  • Conclusion: The findings indicate that decreased SOD2 expression is a notable molecular feature of brain neoplasms. miRNAs identified through HMDD may play a critical role in this downregulation, potentially contributing to tumorigenesis. These miRNAs and their interaction with SOD2 represent promising biomarkers and therapeutic targets for future research in brain tumor biology.
  • Keywords: SOD2; GEO2R; GSE15824; HMDD; microRNA; Gene Expression; Tumorigenesis.

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