ساخت اکانت کاربری رایگان

مقالات پذیرفته شده کنگره

  • صفحه نخست
  • مقالات پذیرفته شده اولین کنگره بین المللی ژنتیک سرطان
بازنشر

  • Effects of Curcumin Supplementation on Inflammatory, Oxidative Stress, and Anticancer Markers in Patients with Chronic Myeloid Leukemia: A Systematic Review

  • Melika Asayesh,1,* Mehrnaz Asayesh,2
    1. Student Research Committee, Hamedan University of Medical Science, Hamadan, Iran.
    2. Student Research Committee, Department of Medical Immunology, Golestan University of Medical Science, Gorgan, Iran.


  • Introduction: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the BCR–ABL fusion gene, which promotes abnormal cell proliferation and survival. Although TKIs have improved patient outcomes, drug resistance and the persistence of leukemic stem cells remain major therapeutic challenges. Curcumin, a natural polyphenolic compound, has attracted significant attention due to its antioxidant and anti-inflammatory properties. Evidence suggests it may act as a complementary agent in CML therapy by modulating cell proliferation, apoptosis, and BCR–ABL signaling pathway. This systematic review examines the antioxidant and anticancer effects of curcumin in CML.
  • Methods: This systematic review was conducted in accordance with the PRISMA guidelines and the PICO framework. A comprehensive literature search was performed from 2015 to 2026 across PubMed, Scopus, and Web of Science. Search strategies for each database combined MeSH terms, keywords related to “Curcumin”, and “Chronic Myeloid Leukemia”. The search was designed to be highly sensitive with no restrictions on study design or publication type. Two independent researchers screened all retrieved articles based on predefined inclusion criteria.
  • Results: A total of 345 articles were identified through the primary search. After screening the titles and abstracts of the articles, the number of articles was reduced to 57, and finally, 16 articles were included in this research based on predefined criteria. The molecular mechanisms underlying curcumin’s activity are multifactorial. Its antioxidant activity scavenges ROS, prevents lipid peroxidation, and protects DNA and proteins, while in malignant cells, it can act as a pro-oxidant. At the signaling level, curcumin inhibits key oncoproteins such as BCR–ABL and STAT5, regulates the cell cycle, activates stress-related pathways including MAPK, AMPK, and JNK, and induces autophagic cell death. These effects are further supported by modulation of PI3K/Akt signaling and enhancement of endogenous antioxidant defenses via Nrf2 activation, while limiting ROS formation through iron chelation.
  • Conclusion: In summary, Curcumin exhibits significant anti-leukemic activity in CML through multi-targeted mechanisms, including the induction of apoptosis and autophagy, regulation of oxidative stress, and inhibition of key oncogenic pathways. Its ability to modulate miRNAs and tumor suppressor signaling further supports its potential to overcome resistance and enhance therapeutic efficacy.
  • Keywords: Curcumin, Chronic myeloid leukemia, Anticancer, Antioxidant, Anti-inflammatory

به خانواده بزرگ کنسر ژنتیکس و ژنومیکس سرطان بپیوندید!

ایجاد حساب کاربری رایگان