ساخت اکانت کاربری رایگان

مقالات پذیرفته شده کنگره

  • صفحه نخست
  • مقالات پذیرفته شده اولین کنگره بین المللی ژنتیک سرطان
بازنشر

  • Breast Cancer and the Microbiota: Insights into Disease Development and Progression

  • Zahra Padin ,1,* Parinaz Shaqaqi,2 Narges Shaqaqi,3 Nastaran Shojaei,4 Mohamad Yasin Tayebi,5 Mehrnoosh khanche zarrin,6
    1. Islamic Azad University, Tehran Medical Sciences Branch
    2. Department of Biology, Payame Noor University, Tehran, Iran
    3. Department of Biology, Islamic Azad University of Medical Sciences, Tehran, Iran
    4. Islamic Azad University, Tehran Medical Sciences Branch
    5. Alborz University of Medical Science
    6. Islamic Azad University, Tehran Medical Sciences Branch


  • Introduction: Breast cancer is shaped by genetic and cellular alterations as well as interactions with the surrounding biological environment. Growing evidence suggests that microbiota may influence immunity, inflammation, hormone and cellular metabolism, and the tumor microenvironment. Both gut and breast tissue microbiota may affect disease development and therapeutic response through systemic and local mechanisms. However, differences in study populations, sampling methods, detection techniques, and treatment exposure limit current understanding. This review summarizes microbiota–breast cancer interactions and their implications for disease progression and therapy.
  • Methods: A narrative literature search was performed using PubMed, Scopus, Web of Science, and Google Scholar. Relevant publications were identified using keywords related to breast cancer, microbiota, microbiome, dysbiosis, microbial metabolites, immune regulation, estrogen metabolism, tumor progression, and treatment response. Selected studies were reviewed and narratively synthesized to examine links between microbial communities and breast cancer development, progression, and therapeutic response, with emphasis on mechanistic findings and changes in the tumor microenvironment.
  • Results: The reviewed evidence identified four major mechanisms linking microbiota to breast cancer. Microbial dysbiosis may alter inflammatory and immune responses within the tumor microenvironment. Microbial β-glucuronidase may affect estrogen metabolism and hormone-dependent tumor growth. Microbial metabolites, including short-chain fatty acids and lactate, may influence tumor metabolism, epigenetic regulation, immunity, and cell survival. Microbiota may also affect responses to chemotherapy, endocrine therapy, and immunotherapy through drug metabolism and host immunity. However, evidence for specific bacterial taxa remains inconsistent and requires further validation.
  • Conclusion: Current evidence indicates a multifactorial relationship between microbiota and breast cancer involving immune regulation, inflammation, estrogen metabolism, microbial metabolites, and tumor metabolism. Microbial alterations may also affect therapeutic response through host immunity and drug metabolism. However, findings on individual bacterial taxa remain inconsistent, and clinical associations do not always indicate causality. Standardized longitudinal studies integrating microbiome, metabolomic, and clinical data are needed to clarify these interactions and assess their potential in biomarkers and personalized treatment.
  • Keywords: Breast cancer,Microbiota,Gut microbiome,Tumor microenvironment,Microbial metabolites

به خانواده بزرگ کنسر ژنتیکس و ژنومیکس سرطان بپیوندید!

ایجاد حساب کاربری رایگان