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  • The Effect of Coffee Consumption on Prostate Cancer in Adult Men

  • samira zare,1,*
    1. Master of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran


  • Introduction: Prostate cancer is the second most common cancer among men worldwide. Its incidence varies significantly and is influenced by geographic location, race, ethnicity, lifestyle factors, and diet. This review aims to discuss the association between prostate cancer and the effects of coffee consumption
  • Methods: Articles were searched in the SID and Google Scholar databases using the keywords and Data related to the mechanisms by which coffee affects prostate cancer control or progression were extracted
  • Results: Beyond its direct antioxidant activity, coffee also stimulates phase II enzyme activity, which plays a crucial role in the detoxification of reactive metabolites. The anti-inflammatory effects of coffee help reduce tissue damage associated with the development of prostate cancer. Coffee induces autophagy, regulates the NF-κB pathway, and decreases the expression of iNOS and inflammatory mediators such as TNF-α, IL-6, IL-8, and CRP. Additionally, coffee modulates various transcription factors and signaling pathways. It has been shown to increase testosterone levels while decreasing sex hormone-binding globulin, estrogen, and prostate-specific antigen. Furthermore, coffee improves insulin resistance and glucose metabolism. Collectively, these effects may contribute to the protective role of coffee against prostate cancer development.
  • Conclusion: Coffee consumption may reduce the risk of prostate cancer and its progression. However, this effect varies in smokers; in this population, consuming more than four cups of coffee per day is associated with a significantly increased risk of prostate cancer
  • Keywords: coffee, cancer, caffeine, prostate cancer, antioxidants

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