ساخت اکانت کاربری رایگان

مقالات پذیرفته شده کنگره

  • صفحه نخست
  • مقالات پذیرفته شده اولین کنگره بین المللی ژنتیک سرطان
بازنشر

  • A Review of Gene therapy in cancer

  • Vida Nikasa,1 Sedigheh Fekri Aval,2,*
    1. Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
    2. Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran


  • Introduction: According to the definition of the World Health Organization (WHO), cancer is the uncontrolled growth and spread of abnormal cells. these abnormal cells invade nearby tissues and spread to other parts of the body through metastasis. in recent years, cancer has become one of the leading causes of death worldwide. Cancers have both genetic and environmental origins, such as diet and smoking. The common method for treating cancer is to kill tumor cells with chemotherapy. These methods have side effects on blood and hair cells. therefore, scientists are looking for methods that have a lethal effect only on tumor cells without affecting other cells. one of the best methods for this purpose is gene therapy. According to the definition of the European Medicines Agency (EMA), a gene therapy medicinal product is a biological product with the following two characteristics: A: Contains an active ingredient containing a recombinant nucleic acid that is administered to humans for the purpose of regulating, repairing, replacing, adding or deleting a genetic sequence, which is therapeutic, prophylactic or diagnostic, B: Or the product of genetic expression of this sequence. Gene transfer is categorized into two main groups: viral and non-viral gene therapy vectors. various types of gene therapy methods used in cancers such as prostate cancer using retroviruses and adenoviruses integrated into the patient's chromosome and using liposomes, and stem cells, using epigenetics in cervical cancer taking advantage of the papillomavirus. in hepatocellular carcinoma has been used engineered HBV-specific TCR-redirected T cells (HBV-TCR T cells), CRISPR/Cas9 through genome editing and targeted therapeutics. also, in colorectal cancer used lentiviruses, adenoviruses, adeno-associated virus (AAV) and papillomavirus as viral vectors and Cationic lipid–DNA complexes (lipoplexes) As a non-viral vector. Liposomes carry various genetic materials such as DNA, siRNA, miRNA. They have been used in ovarian cancer. This review study examines gene therapy in prostate, cervical, colorectal, and ovarian cancers and the types of gene therapy methods used in them.
  • Methods: A targeted search was done in electronic databases such as PubMed, google scholar and science direct. Relevant and up-to-date studies were selected to further analysis.
  • Results: According to a review of studies conducted on the use of gene therapy, compared to previous conventional treatments, with the power to destroy cancer cells without damaging adjacent cells, it allows for precise, molecular treatment for aggressive and life-threatening diseases. Also, the use of viruses with the power to transfer healthy genes into cells with defective genes can be used in this new therapeutic method, given the power of viral genes to replace genes in human cells.
  • Conclusion: Researchers have concluded that Due to the aggressive nature of cancer, some of them are incurable, especially in the advanced stages of the disease. On the other hand, due to the side effects of some cancer treatments, such as chemotherapy, researchers have concluded that gene therapy could be a promising therapeutic and gene-modifying option for cancer.
  • Keywords: Gene therapy, Delivery, Vector, Stem cell, Epigenetic

به خانواده بزرگ کنسر ژنتیکس و ژنومیکس سرطان بپیوندید!

ایجاد حساب کاربری رایگان