ساخت اکانت کاربری رایگان

مقالات پذیرفته شده کنگره

  • صفحه نخست
  • مقالات پذیرفته شده اولین کنگره بین المللی ژنتیک سرطان
بازنشر

  • Genetic and Molecular Foundations of Ovarian Cancer: A

  • Atefeh shirkavand,1 Hamideh Mozaffari,2 Bahar Razavi,3,* Rahil Mirzaei,4
    1. Islamic Azad University, TehranShomal
    2. University of Maragheh, Maragheh, Iran
    3. Kasra Hospital, Tehran, Iran
    4. Pishva University, Varamin, Iran


  • Introduction: Introduction: Ovarian cancer is one of the deadliest types of cancer affecting women because it does not show any specific signs during its early stages and is usually diagnosed only in later advanced stages. The causes of ovarian cancer are mutations in DNA repair genes, deregulation of tumor suppressor genes, and epigenetic alterations in DNA. Although several studies conducted in Iran have investigated BRCA mutations in Iranian patients, there is a lack of review studies that relate the findings to international evidence. This narrative review aims to summarize the existing evidence on the gene mutations and molecular pathways causing ovarian cancer.
  • Methods: Materials and Methods: Articles published between 2000 and 2025 were retrieved from PubMed, Scopus, and Web of Science. Studies containing genetic or molecular data related to ovarian cancer were included, while conference abstracts and studies lacking such data were excluded. Ultimately, 25 eligible studies were analyzed using a content analysis approach.
  • Results: Result: In the 25 published studies, the most frequent results were BRCA1 and BRCA2 mutations. Around 25% of references reviewed also mentioned deviation in TP53. The violation of the PTEN gene, connected with the activation of the PI3K/AKT/mTOR signaling pathway, appeared with the frequency of approximately 20%. Pathway MAPK/ERK played a role in uncontrolled proliferation of cells in approximately 10% of research works studied. Epigenetic modifications, such as methylation of DNA as well as dysregulation of miR-141 and miR-125b, were noted as the gene silencing mechanisms in around 10% of articles examined.
  • Conclusion: Conclusion : Ovarian cancer arises from multiple causes and has a complicated genetic and molecular background. It involves numerous factors such as BRCA1 and BRCA2 mutations, TP53 and PTEN dysfunction, the PI3K/AKT/mTOR pathway, and MAPK/ERK signaling pathway dysregulation. Because BRCA variants are common in Iran, genetic screening of the first-degree family of ovarian cancer patients, in conjunction with PARP inhibitors, serves as an effective way of identifying and managing the disease in this population.
  • Keywords: Keywords: Ovarian Cancer; Molecular Genetics; BRCA1/BRCA2; Epigenetics; Molecular Pathways

به خانواده بزرگ کنسر ژنتیکس و ژنومیکس سرطان بپیوندید!

ایجاد حساب کاربری رایگان